Molecular basis of human neutrophil antigen 2 ( HNA ‐2) expression
نویسندگان
چکیده
منابع مشابه
A Case of Neonatal Alloimmune Neutropenia Associated with Anti-Human Neutrophil Antigen-1a (HNA-1a) Antibody
Neonatal alloimmune neutropenia (NAN) is an uncommon disease of the newborn provoked by the maternal production of neutrophil-specific alloantibodies, whereby neutrophil IgG antibodies cross the placenta and induce the destruction of fetal neutrophils. Affected newborns are usually identified by the occurrence of bacterial infections. The most frequent antigens involved in NAN are the human neu...
متن کاملMolecular basis of NB1 (HNA-2a, CD177) deficiency.
Alloimmunization to the neutrophil antigen NB1 (HNA-2a, CD177) can result in immune neutropenia and transfusion-related acute lung injury. Recently, we were able to elucidate the primary structure of NB1. To shed light also on the molecular basis of the NB1-negative phenotype, we studied the neutrophils of 2 women with NB1-specific alloantibodies for intracellular and extracellular NB1 expressi...
متن کاملBrief report Molecular basis of NB1 (HNA-2a, CD177) deficiency
Alloimmunization to the neutrophil antigen NB1 (HNA-2a, CD177) can result in immune neutropenia and transfusionrelated acute lung injury. Recently, we were able to elucidate the primary structure of NB1. To shed light also on the molecular basis of the NB1-negative phenotype, we studied the neutrophils of 2 women with NB1-specific alloantibodies for intracellular and extracellular NB1 expressio...
متن کاملCorrection: Genetic Mechanism of Human Neutrophil Antigen 2 Deficiency and Expression Variations
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The publisher apologizes for the error. an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
متن کاملGenetic Mechanism of Human Neutrophil Antigen 2 Deficiency and Expression Variations
Human neutrophil antigen 2 (HNA-2) deficiency is a common phenotype as 3-5% humans do not express HNA-2. HNA-2 is coded by CD177 gene that associates with human myeloproliferative disorders. HNA-2 deficient individuals are prone to produce HNA-2 alloantibodies that cause a number of disorders including transfusion-related acute lung injury and immune neutropenia. In addition, the percentages of...
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ژورنال
عنوان ژورنال: ISBT Science Series
سال: 2019
ISSN: 1751-2816,1751-2824
DOI: 10.1111/voxs.12536